Midlife in the United States (MIDUS 2): Neuroscience Project, 2004-2009

Resource Type
Dataset : experimental data, survey data
  • Ryff, Carol D.
  • Davidson, Richard J.
Other Title
  • MIDUS 2 Neuroscience Project (Alternative Title)
  • Version 2 (Subtitle)
Collective Title
  • Midlife in the United States (MIDUS) Series
Publication Date
Publication Place
Ann Arbor, Michigan
  • Inter-University Consortium for Political and Social Research
Funding Reference
  • United States Department of Health and Human Services. National Institutes of Health. National Institute on Aging
Free Keywords
Schema: ICPSR
adults; anxiety; emotional states; neuroscience; psychosocial assessment
  • Abstract

    The Neuroscience study is Project 5 of the MIDUS longitudinal study, a national survey of more than 7,000 Americans (aged 25 to 74) begun in 1994. The purpose of the larger study was to investigate the role of behavioral, psychological, and social factors in understanding age-related differences in physical and mental health. With support from the National Institute on Aging, a longitudinal follow-up of the original MIDUS samples [core sample (N = 3,487), metropolitan over-samples (N = 757), twins (N = 957 pairs), and siblings (N = 950)] was conducted in 2004-2006. The Neuroscience Project of MIDUS 2 contains data from 331 respondents. These respondents include two distinct subsamples, all of whom completed both the Project 1 Survey and the Project 4 biomarker assessment at University of Wisconsin-Madison: (1) longitudinal (n = 223) and (2) Milwaukee (n = 108). The Milwaukee group contained individuals who participated in the baseline MIDUS Milwaukee study, initiated in 2005. The purpose of the Neuroscience Project was to examine the central circuitry associated with individual differences in affective style that represent a continuum from vulnerability to resilience, and characterize some of the peripheral consequences of these central profiles for biological systems that may be relevant to health. The primary aims were to: (1) characterize individual differences in both emotional reactivity and emotional recovery using psychophysiological measures such as corrugator electromyography and eyeblink startle magnitude, (2) characterize individual differences in brain morphology, in particular amygdala and hippocampal volume, using structural magnetic resonance imaging (MRI), (3) characterize individual differences in activity within the neural circuitry of emotion regulation using both electroencephalography and fMRI, and (4) test the ability of the central indices in this project to predict the comprehensive array of health, cognitive, psychological, social, and life challenge factors assessed in the other MIDUS projects. To probe individual differences in emotional reactivity and recovery (a key component of regulation) the Neuroscience Project examined both psychophysiological and fMRI measures during the presentation of emotional (positive and negative) and neutral pictures, and these same measures during a post-picture period. The logic of this strategy is that continued activation during the recovery period following a negative stimulus is indicative of poor automatic emotion regulation. Respondents in the Neuroscience Project are a representative subsample of the MIDUS (Midlife in the United States) survey. The image data are not available through NACDA/ICPSR; please read the collection notes for more information.
  • Abstract

    The purpose of the Neuroscience Project was to examine the central circuitry associated with individual differences in affective style that represent a continuum from vulnerability to resilience, and characterize some of the peripheral consequences of these central profiles for biological systems that may be relevant to health.
  • Methods

    ICPSR data undergo a confidentiality review and are altered when necessary to limit the risk of disclosure. ICPSR also routinely creates ready-to-go data files along with setups in the major statistical software formats as well as standard codebooks to accompany the data. In addition to these procedures, ICPSR performed the following processing steps for this data collection: Created online analysis version with question text.; Checked for undocumented or out-of-range codes..
  • Methods

    Presence of Common Scales: DPES- Dispositional Positive Emotion Scale; PANAS- Positive and Negative Affect Schedule; RASQ- Reactivity to Affective Stimuli Quesionnaire; STXS- Spielberger State-Trait Anxiety Inventory; ERQ- Emotional Regulation Questionnaire
  • Methods

    Response Rates: The response rates for each subsample were: (1) longitudinal (67.1 percent) and (2) Milwaukee (53.7 percent).
  • Abstract


    • DS1: Midlife in the United States (MIDUS 2): Neuroscience Project, 2004-2009
Temporal Coverage
  • Time period: 2004--2009
  • 2004 / 2009
  • Collection date: 2004-08--2009-05
  • 2004-08 / 2009-05
Geographic Coverage
  • United States
Sampled Universe
Adult non-institutionalized population in the contiguous United States. Smallest Geographic Unit: No geographic information is included other than for the Milwaukee cases.
All respondents participating in MIDUS 2 (ICPSR 4652) or the Milwaukee study (ICPSR 22840) who completed both Project 1 and Project 4 at the University of Wisconsin-Madison were eligible to participate in the Neuroscience assessments.
Collection Mode
  • cognitive assessment test
  • self-enumerated questionnaire
2019-01-23 This collection was updated to include filter, date, and additional electroencephalography (EEG) related variables. The study title was also updated to include the study time period.2017-11-20 This collection is being updated, per request from the PI, to reflect a title change; the corresponding downloadable files are only being updated to reflect the title change, where applicable.2011-10-25 The document titled DDI codebook has been renamed Codebook. Funding institution(s): United States Department of Health and Human Services. National Institutes of Health. National Institute on Aging (P01-AG020166).
This version of the study is no longer available on the web. If you need to acquire this version of the data, you have to contact ICPSR User Support (help@icpsr.umich.edu).
Alternative Identifiers
  • 28683 (Type: ICPSR Study Number)
  • Is previous version of
    DOI: 10.3886/ICPSR28683.v3
  • Is new version of
    DOI: 10.3886/ICPSR28683.v1
  • van Reekum, C.M., Schaefer, S.M., Lapate, R.C., Norris, C.J., Tun, P.A., Lachman, M.E., Ryff, C.A., Davidson, R.J.. Aging is associated with a prefrontal lateral-medial shift during picture-induced negative affect. Social Cognitive and Affective Neuroscience.13, (2), 156-163.2018.
    • ID: 10.1093/scan/nsx144 (DOI)
  • Hostinar, Camelia E., Davidson, Richard J., Graham, Eileen K., Mroczek, Daniel K., Lachman, Margie E., Seeman, Teresa E., van Reekum, Carien M., Miller, Gregory E.. Frontal brain asymmetry, childhood maltreatment, and low-grade inflammation at midlife. Psychoneuroendocrinology.75, 152-163.2017.
    • ID: 10.1016/j.psyneuen.2016.10.026 (DOI)
  • Craig, Curtis, Neilson, Brittany, Overbeek, Randy W.. An association between nature exposure and physiological measures of emotion and cognition. Proceedings of the Human Factors and Ergonomics Society Annual Meeting.60, 1369-1373.2016.
    • ID: 10.1177/1541931213601316 (DOI)
  • Shkurko, Yulia S.. The speed and accuracy of decision making managers and subordinates. Siberian Journal of Psychology.59, 2016.
  • Hosseinbor, A.P., Chung, M.K., Koay, C.G., Schaefer, S.M., van Reekum, C.M., Schmitz, L.P., Sutterer, M., Alexander, A.L., Davidson, R.J.. 4D hyperspherical harmonic (HyperSPHARM) representation of surface anatomy: A holistic treatment of multiple disconnected anatomical structures. Medical Image Analysis.2015.
    • ID: 10.1016/j.media.2015.02.004 (DOI)
  • Reading, Stephanie Rummans. Relationship between Psychosocial Stress and Allostatic Load: Findings from the MIDUS study. Dissertation, University of California, Los Angeles. 2015.
  • Chung, Moo K., Kim, Seung-Goo, Schaefer, Stacey M., van Reekum, Carien M., Peschke-Schmitz, Lara, Sutterer, Matthew J., Davidson, Richard J.. Improved statistical power with a sparse shape model in detecting an aging effect in the hippocampus and amygdala. Proceedings - Society of Photo-Optical Instrumentation Engineers.90340Y2014.
    • ID: 10.1117/12.2036497 (DOI)
  • Lapate, R.C., van Reekum, C.M., Schaefer, S.M., Greischar, L.L., Norris, C.J., Bachhuber, D.R., Ryff, C.D., Davidson, R.J.. Prolonged marital stress is associated with short-lived responses to positive stimuli. Psychophysiology.2014.
    • ID: 10.1111/psyp.12203 (DOI)
  • Berwick, Amy Courtenay. Relationships Between Education, Personality, Change in Personality Traits, and the Use of Mental Health Services Among Middle-aged Women Over a 10-year Time Span. Dissertation, University of North Carolina at Charlotte. 2013.
  • Heller, A.S., van Reekum, C.M., Schaefer, S.M., Lapate, R.C., Radler, B.T., Ryff, C.D., Davidson, R.J.. Sustained ventral striatal activity predicts eudaimonic well-being and cortisol output. Psychological Science.2013.
  • Hosseinbor, A.P., Chung, M.K., Schaefer, S.M., van Reekum, C.M., Peschke-Schmitz, L., Sutterer, M., Alexander, Andrew L., Davidson, R.J.. 4D hyperspherical harmonic (HyperSPHARM) representation of multiple disconnected brain subcortical structures. Medical Image Computing and Computer-assisted Intervention--MICCAI 2013. 16th International Conference Nagoya, Japan, September 22-26, 2013 Proceedings, Part I.Heidelberg: Springer. 2013.
  • Schaefer, S.M., Morozink Boylan, J., van Reekum, C.M., Lapate, R.C., Norris, C.J., Ryff, C.D., Davidson, R.J.. Purpose in life predicts better emotional recovery from negative stimuli. PLOS One.8, (11), e803292013.
    • ID: 10.1371/journal.pone.0080329 (DOI)
  • Javaras, K.N., Schaefer, S.M., van Reekum, C.M., Lapate, R.C., Greischar, L.L., Bachhuber, D.R., Love, G.D., Ryff, C.D., Davidson, R.J.. Conscientiousness predicts greater recovery from negative emotion. Emotion.12, (5), 875-881.2012.
    • ID: 10.1037/a0028105 (DOI)
  • van Reekum, Carien M., Schaefer, Stacey M., Lapate, Regina C., Norris, Catherine J., Greischar, Lawrence L., Davidson, Richard J.. Aging is associated with positive responding to neutral information but reduced recovery from negative information. Social Cognitive and Affective Neuroscience.6, (2), 177-185.2011.
    • ID: 10.1093/scan/nsq031 (DOI)
  • Ward, Megan Elizabeth. Does 'Comfort Food' Work? How Using Food to Cope Is Associated with Self-Reported Physical Health and Weight-Related Health. Masters thesis, Pennsylvania State University. 2009.

Update Metadata: 2019-01-23 | Issue Number: 8 | Registration Date: 2015-06-16