The Research Data Management Working Group (AK FDM) of the Universities in Baden-Württemberg (Germany) has produced a "Guide - Responsible Handling of Research Data" (DE: Leitfaden zum verantwortungsvollen Umgang mit Forschungsdaten). It includes Best practice recommendations differentiated according to the target groups of researchers, infrastructure institutions and universities. In a compact and clear form, the guide addresses the most important aspects such as framework conditions, stakeholders, implementation and costs for handling research data. The central recommendation for the target groups is listed in a table at the beginning of each point. The guideline has been endorsed by the "AG der Direktorinnen und Direktoren der Universitäts- und Landesbibliotheken Baden-Württembergs" (AGBibDir) and the "Arbeitskreis der Leiterinnen und Leiter der wissenschaftlichen Rechenzentren in Baden-Württemberg" (ALWR). Now it will be passed on to the rectorates and presidiums of the nine Universities for implementation. The guide is licensed under CC BY 4.0 International and the authors welcome a wide Re-use.